Selected Contribution: IGF-I antibody prevents increases in protein synthesis in epitrochlearis muscles from refed, diabetic rats.

@article{Fedele2001SelectedCI,
  title={Selected Contribution: IGF-I antibody prevents increases in protein synthesis in epitrochlearis muscles from refed, diabetic rats.},
  author={Mark J. Fedele and Thomas C. Vary and Peter A. T. Farrell},
  journal={Journal of applied physiology},
  year={2001},
  volume={90 3},
  pages={
          1166-73; discussion 1165
        }
}
The purpose of this study was to examine whether immune neutralization of muscle-produced insulin-like growth factor I (IGF-I) would prevent an appropriate anabolic response to refeeding in diabetic rats. Male Sprague-Dawley rats were made diabetic by partial pancreatectomy and were randomly assigned to be either control-fed, fasted, or fasted-refed (n = 7-8 per group). Diabetes decreased rates of protein synthesis and increased rates of protein degradation in incubated epitrochlearis muscles… CONTINUE READING

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