Select cancer testes antigens of the MAGE-A, -B, and -C families are expressed in mast cell lines and promote cell viability in vitro and in vivo.

@article{Yang2007SelectCT,
  title={Select cancer testes antigens of the MAGE-A, -B, and -C families are expressed in mast cell lines and promote cell viability in vitro and in vivo.},
  author={Bing Yang and Sean M O'Herrin and Jianqiang Wu and Shannon R. Reagan-Shaw and Yongsheng Ma and Minakshi Nihal and B. Jack Longley},
  journal={The Journal of investigative dermatology},
  year={2007},
  volume={127 2},
  pages={267-75}
}
MAGE antigens are proteins that are normally expressed only in gametes but are often aberrantly expressed in melanomas, hematopoietic malignancies, and other "cancers". The functions of most MAGE proteins are unknown. Data have accumulated suggesting expression of MAGE proteins by malignant cells may contribute to advanced disease or resistance to chemotherapy, but direct evidence supporting this hypothesis is lacking. We show here that small interfering RNA (siRNA) suppression of MAGE-A, -B… CONTINUE READING

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