Select 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors vary in their ability to reduce egg yolk cholesterol levels in laying hens through alteration of hepatic cholesterol biosynthesis and plasma VLDL composition.

@article{Elkin1999Select3A,
  title={Select 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors vary in their ability to reduce egg yolk cholesterol levels in laying hens through alteration of hepatic cholesterol biosynthesis and plasma VLDL composition.},
  author={Robert G. Elkin and Zhihong Yan and Yuan Zhong and Shawn S. Donkin and Kimberly K. Buhman and Jon Story and John J. Turek and Robert E. Porter and Maureen M. Anderson and Reynold Homan and R. S. Newton},
  journal={The Journal of nutrition},
  year={1999},
  volume={129 5},
  pages={1010-9}
}
The inability to markedly attenuate cholesterol levels in chicken eggs has led to speculation that cholesterol is essential for yolk formation and that egg production would cease when yolk cholesterol deposition was inadequate for embryonic survival. However, this critical level hypothesis remains unproven. Here, we determine the relative responsiveness of laying hens to three select inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), the rate-limiting enzyme of cholesterol… CONTINUE READING

Similar Papers

Loading similar papers…