Selagoline, A new Alkaloid from Huperzia Selago

  title={Selagoline, A new Alkaloid from Huperzia Selago},
  author={D. St{\ae}rk and Jesper Larsen and L. A. Larsen and E. S. Olafsdottir and M. Witt and J. Jaroszewski},
  journal={Natural Product Research},
  pages={197 - 203}
A new natural product, named selagoline, and two known alkaloids, huperzine A and serratidine, were isolated from Huperzia selago (Lycopodiaceae) collected in Iceland. Their structures were determined using 600 and 800 MHz one- and two-dimensional NMR methods supported by Fourier-transform mass spectrometry. Possible role of selagoline as a precursor of 5,15-oxidolycopodane, a component of the classical alkaloids L28 and L31, is discussed. 
Medical Ethnobotany , Phytochemistry , and Bioactivity of the Ferns of Moorea , French Polynesia
The purpose of this paper is to create a resource for the future scientific study of the medical ethnobotany and bioactivity of pteridophytes on Moorea, French Polynesia. Pteridophytes comprise aExpand
The traditional uses, secondary metabolites, and pharmacology of Lycopodium species
Lycopodium is a genus of the family Pteridophytes, which is widely distributed in temperate and tropical climates and tropical mountains. Plants of genus Lycopodium are ancient medicinal plants whichExpand
The Genus Diphasiastrum and Its Lycopodium Alkaloids.
In this review, reported alkaloids and their distribution patterns across these species along with taxonomical and bioactivity considerations are reviewed and discussed. Expand
Alkaloid fingerprinting resolves Huperzia selago genotypes in Iceland
The potential of alkaloid fingerprints in resolving deep taxonomic groups and selecting plant taxa of medicinal importance is demonstrated as demonstrated in previously reported Icelandic Huperzia selago genotypes. Expand
Huperzine A from Huperzia species--an ethnopharmacolgical review.
HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. Expand
Infraspecific Variation of Huperzine A and B in Icelandic Huperzia selago Complex.
The phylogenetic analysis suggests that previously proposed Huperzia appressa and HuperZia arctica should not be considered species, but rather subspecies of H. selago. Expand
Phytochemicals from fern species: potential for medicine applications
An updated review of the literature on the occurrence, chemotaxonomy and physiological activity of fern secondary metabolites is provided, covering recent findings concerning the bioactive phytochemicals and pharmacology of f Fern species. Expand
The Lycopodium alkaloids.
The effect of HupA and other cholinesterase inhibitors (anti-AD drugs) on acetylcholine esterase activity in the rat cortex and butylCholine esters activity are compared. Expand
A Review on Pteridophyte Antioxidants and their Potential Role in Discovery of New Drugs
Knowledge of antioxidant potentiality of pteridophytes and their remedial activity against different diseases is remain incomplete, hence, an exclusive study is essential for better understanding and exploration of potentialITY of antioxidant from pterodophytes. Expand
A review of the use of pteridophytes for treating human ailments
Many pteridophytes examined have properties that could be used in alternative medicine for treatment of various human illnesses, and taxa from the Pteridaceae, Polypodiaceae, and Adiantaceae exhibited significant medicinal activity. Expand


Alkaloids of Lycopodiumselago. On the identity of selagine with huperzine A and the structure of a related alkaloid
Selagine, an alkaloid of Lycopodiumselago, is shown to be identical with huperzine A (2). A minor alkaloid, C15H18N2O2, isolated from L. selago is found to be 6β-hydroxyhuperzine A (4). Keywords:Expand
Two Novel Lycopodium Alkaloids from Huperzia serrata
Huperzine Q (1) and N-oxyhuperzine Q (2), two novel irregular fawcettimine-type Lycopodium alkaloids were isolated from the CHCl3 fraction of the basic material of the whole plant of the ChineseExpand
Three lycopodium alkaloid N-oxides from Huperzia serrata.
Three lycopodium alkaloid N-oxides, huperzine J, K and L, were obtained from Huperzia serrata and their structures were elucidated by spectroscopic methods and the relative configurations of 1 and 3 were established via NOESY NMR observations. Expand
New lycopodium alkaloids from Huperzia serrata.
Three new lycopodium alkaloids were isolated from the herb Huperzia serrata along with a known compound, phlegmariurine B, which were elucidated based on spectroscopic studies. Expand
Three New Hydroxylated Serratidine Alkaloids from Huperzia Serrata
Three hydroxylated serratidine alkaloids and a known compound were isolated from the CHCl 3 fraction of basic materials of whole plant of the Chinese medicinal herb Huperzia serrata. Expand
Huperzine P, a novel Lycopodium alkaloid from Huperzia serrata
Abstract Huperzine P ( 1 ), a new irregular fawcettimine-type Lycopodium alkaloid, was isolated from Huperzia serrata and the absolute stereostructure was established by 2D NMR and X-rayExpand
Huperzine R, a novel 15-carbon Lycopodium alkaloid from Huperzia serrata.
Huperzine R (2), a novel 15-carbon Lycopodium alkaloid, was isolated from the whole plant of Huperzia serrata, and the relative configuration was established using spectroscopic and X-rayExpand
A new type of lycopodium alkaloid, lycoposerramine-A, from Lycopodium serratum Thunb.
A novel alkaloid, lycoposerramine-A (1), which has a 1,2,4-oxadiazolidin-5-one residue in the molecule, was isolated from the club moss Lycopodium serratum Thunb by spectroscopic and X-ray analyses. Expand
The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity
Huperzine A and B, two new Lycopodium alkaloids isolated from Huperziaserrata (Thunb.) Trev., are shown to possess structures 1 and 3, respectively, on the basis of chemical and spectroscopic data.
Seven new Lycopodium alkaloids, lycoposerramines-C, -D, -E, -P, -Q, -S, and -U, from Lycopodium serratum Thunb.
Seven new alkaloids, lycoposerramines-C, -D, -E, -P, -Q, -S, and -U, having novel fawcettimine-related structures, were isolated from the club moss Lycopodium serratum Thunb.