Seizures in dominantly inherited Alzheimer disease.

  title={Seizures in dominantly inherited Alzheimer disease.},
  author={Aline Zarea and Camille Charbonnier and Anne Rovelet-Lecrux and Ga{\"e}l Nicolas and St{\'e}phane Rousseau and Alaina Borden and J{\'e}r{\'e}mie Pariente and I Le Ber and Florence Pasquier and Mait{\'e} Formaglio and Olivier Martinaud and Adeline Rollin-Sillaire and Marie Sarazin and Bernard Croisile and Claire Boutoleau-Bretonni{\'e}re and Mathieu Ceccaldi and Audrey Gabelle and Ludivine Chamard and Fr{\'e}d{\'e}ric Blanc and François Sellal and Claire Paquet and Dominique Campion and Didier Hannequin and David Wallon},
  volume={87 9},
OBJECTIVE To assess seizure frequency in a large French cohort of autosomal dominant early-onset Alzheimer disease (ADEOAD) and to determine possible correlations with causative mutations. METHODS A national multicentric study was performed in patients with ADEOAD harboring a pathogenic mutation within PSEN1, PSEN2, APP, or a duplication of APP, and a minimal follow-up of 5 years. Clinical, EEG, and imaging data were systematically recorded. RESULTS We included 132 patients from 77 families… CONTINUE READING
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