Seizures beget seizures in temporal lobe epilepsies: the boomerang effects of newly formed aberrant kainatergic synapses.

@article{BenAri2008SeizuresBS,
  title={Seizures beget seizures in temporal lobe epilepsies: the boomerang effects of newly formed aberrant kainatergic synapses.},
  author={Yehezkel Ben-Ari and Val{\'e}rie Cr{\'e}pel and Alfonso Represa},
  journal={Epilepsy currents},
  year={2008},
  volume={8 3},
  pages={68-72}
}
Do temporal lobe epilepsy (TLE) seizures in adults promote further seizures? Clinical and experimental data suggest that new synapses are formed after an initial episode of status epilepticus, however their contribution to the transformation of a naive network to an epileptogenic one has been debated. Recent experimental data show that newly formed aberrant excitatory synapses on the granule cells of the fascia dentate operate by means of kainate receptor-operated signals that are not present… CONTINUE READING

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