Seizures and epilepsy in herpes simplex virus encephalitis: current concepts and future directions of pathogenesis and management

@article{Sellner2012SeizuresAE,
  title={Seizures and epilepsy in herpes simplex virus encephalitis: current concepts and future directions of pathogenesis and management},
  author={J. Sellner and E. Trinka},
  journal={Journal of Neurology},
  year={2012},
  volume={259},
  pages={2019-2030}
}
Mortality related to herpes simplex virus encephalitis (HSE) dropped dramatically with the systematic initiation of antiviral treatment in encephalitic syndromes. Further efforts need to be taken to reduce long-term morbidity in the survivors. In this regard, the high rate of postencephalitic epilepsy, which is frequently refractory to medical treatment, contributes significantly to the unfavorable clinical outcome of the disease. Seizures during the acute phase of HSE are the main risk for the… Expand
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References

SHOWING 1-10 OF 119 REFERENCES
Viral encephalitis and epilepsy
TLDR
Prospective studies are required to document the risk of late unprovoked seizures and epilepsy following viral encephalitis due to different viruses as well as to determine the clinical characteristics, course, and outcome of post‐encephalitic epilepsy. Expand
Herpes simplex encephalitis: a case report.
TLDR
The prognosis for patients with HSE has been dramatically improved by the availability of specific antiviral therapy; sequelae in surviving patients may include severe neurological deficits, seizures, and/or neuropsychological dysfunctions that greatly impair quality of life. Expand
Herpes simplex encephalitis: adolescents and adults.
TLDR
Investigative efforts are assessing the prognostic value of quantitative PCR detection of viral DNA at the onset of therapy as well as at the completion of therapy and the contribution of prolonged antiviral therapy to improved neurologic outcome. Expand
Incidence and pathogenesis of clinical relapse after herpes simplex encephalitis in adults
TLDR
The lack of demonstrable HSV DNA in CSF, the lack of acute CSF signs and the lackOf signs of neural and glia cells destruction indicate that a direct viral cytotoxicity is not the major pathogenic mechanism in relapse, and the pronounced CSF proinflammatory immunological response and the relative lack of CSF anti–inflammatory cytokine IL–10 response suggest immunologically–mediated pathogenicity. Expand
Presurgical evaluation in patients with inflammatory lesions: meningitis, encephalitis, and Rasmussen’s syndrome
TLDR
The characteristics of chronic epilepsies following the central nervous system (CNS) infections and the presurgical evaluation in patients with inflammatory lesions are described and functional imaging techniques may assist in assessing the functional integrity of the hemisphere contralateral to the epileptogenic lesion. Expand
Herpes simplex encephalitis. Clinical Assessment.
TLDR
Clinical data from 113 patients in whom the diagnosis was proved by viral isolation of herpes simplex encephalitis shows that diagnosis can be confirmed only by brain biopsy. Expand
Seizures in encephalitis: Predictors and outcome
TLDR
In encephalitis, seizures occur in 42.6% patients especially in children with low GCS score and having cortical involvement on MRI, which is not related to mortality but associated with poor outcome. Expand
Immunocytochemical characterization of long‐term persistent immune activation in human brain after herpes simplex encephalitis
The clinical, virological and immunocytochemical features of three children who recovered from acute herpes simplex encephalitis (HSE) before the age of 2 years, and who developed secondary severeExpand
Viral encephalitis: a clinician’s guide
TLDR
The Liverpool approach to the investigation and treatment of adults with suspected viral encephalitis is discussed, and the Liverpool algorithm for investigation and Treatment of immunocompetent adults with suspicions of viral encephalitis is introduced. Expand
Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir.
  • Y. Ito, H. Kimura, +4 authors T. Morishima
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2000
TLDR
Exacerbation of HSE in children may be more common than previously recognized and it is suggested that the replication of HSV or another viral pathogen caused a second encephalitic illness in some cases. Expand
...
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2
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4
5
...