Seizure susceptibility alteration through 5-HT3 receptor: Modulation by nitric oxide

  title={Seizure susceptibility alteration through 5-HT3 receptor: Modulation by nitric oxide},
  author={Taha Gholipour and Mehdi Keshavarz Ghasemi and Kiarash Riazi and Majid Ghaffarpour and Ahmad Reza Dehpour},
There is some evidence that epileptic seizures could be induced or increased by 5-hydroxytryptamine (5-HT) attenuation, while augmentation of serotonin functions within the brain (e.g. by SSRIs) has been reported to be anticonvulsant. This study was performed to determine the effect of selective 5-HT(3) channel/receptor antagonist granisetron and agonist SR57227 hydrochloride on the pentylenetetrazole (PTZ)-induced seizure threshold in mice. The possible interaction of this effect with… CONTINUE READING


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