Seizure resistance without parkinsonism in aged mice after tau reduction.

  title={Seizure resistance without parkinsonism in aged mice after tau reduction.},
  author={Zhiyong Li and Alicia M Hall and Mark Kelinske and Erik D Roberson},
  journal={Neurobiology of aging},
  volume={35 11},
Tau is an emerging target for Alzheimer's disease (AD) and other conditions with epileptiform activity. Genetic tau reduction (in Tau(+/-) and Tau(-/-) mice) prevents deficits in AD models and has an excitoprotective effect, increasing resistance to seizures, without causing apparent neuronal dysfunction. However, most studies of tau reduction have been conducted in <1-year-old mice, and the effects of tau reduction in aged mice are less clear. Specifically, whether the excitoprotective effects… CONTINUE READING
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