Seizure-like events in disinhibited ventral slices of adult rat hippocampus.

@article{Borck1999SeizurelikeEI,
  title={Seizure-like events in disinhibited ventral slices of adult rat hippocampus.},
  author={Cornelius Borck and John G. R. Jefferys},
  journal={Journal of neurophysiology},
  year={1999},
  volume={82 5},
  pages={2130-42}
}
Epileptic discharges lasting 2-90 s, were studied in vitro in slices from the ventral hippocampus of adult rats, in which inhibition was blocked acutely with bicuculline methiodide (BMI, 5-30 microM) and potassium ([K(+)](o)) raised to 5 mM. These seizure-like events (SLEs) comprised three distinct phases, called here primary, secondary, and tertiary bursts. Primary bursts lasted 90-150 ms. Secondary bursts lasted a further 70-250 ms, comprising a short series of afterdischarges riding on the… CONTINUE READING