Seizure-induced structural and functional changes in the rat hippocampal formation: comparison between brief seizures and status epilepticus.

@article{Cardoso2011SeizureinducedSA,
  title={Seizure-induced structural and functional changes in the rat hippocampal formation: comparison between brief seizures and status epilepticus.},
  author={Armando Cardoso and Elena A Lukoyanova and Maria Dulce Cordeiro Madeira and Nikolai V Lukoyanov},
  journal={Behavioural brain research},
  year={2011},
  volume={225 2},
  pages={538-46}
}
Prolonged seizures produce death of hippocampal neurons, which is thought to initiate epileptogenesis and cause a disruption of hippocampally mediated behaviors. This study aimed to evaluate behavioral and neuroanatomical changes induced by brief seizures and to compare them with changes induced by prolonged seizures. Adult rats were administered 6 brief seizures, elicited by electroshock (ECS). Prolonged seizures (status epilepticus, SE) were induced by pilocarpine. Two months later, the rats… CONTINUE READING

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