Seizure-induced alterations in the metabolism of hippocampal opioid peptides suggest opioid modulation of seizure-related behaviors.

@article{Hong1988SeizureinducedAI,
  title={Seizure-induced alterations in the metabolism of hippocampal opioid peptides suggest opioid modulation of seizure-related behaviors.},
  author={J. S. Hong and Jacqueline F McGinty and Laura M. Grimes and Tomoyuki Kanamatsu and Johnny F. Obie and Clifford L. Mitchell},
  journal={NIDA research monograph},
  year={1988},
  volume={82},
  pages={
          48-66
        }
}
The evidence accumulated so far indicates that seizure activity exerts profound changes on the metabolism of opioid peptides in the hippocampus. Our data consistently show a large transient decrease in dynorphin and a modest decrease in enkephalin in the hippocampus following either a single ECS or KA injection. These initial reductions, which are indicative of increased release, may trigger the biosynthetic process of hippocampal opioids and result in an overproduction of the peptides seen in… CONTINUE READING

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