Seizure control with thermal energy? Modeling of heat diffusivity in brain tissue and computer-based design of a prototype mini-cooler.

@article{Osorio2009SeizureCW,
  title={Seizure control with thermal energy? Modeling of heat diffusivity in brain tissue and computer-based design of a prototype mini-cooler.},
  author={Ivan Osorio and Fon-Chieh Chang and Nachappa Gopalsami},
  journal={Epilepsy & behavior : E&B},
  year={2009},
  volume={16 2},
  pages={203-11}
}
Automated seizure blockage is a top priority in epileptology. Lowering nervous tissue temperature below a certain level suppresses abnormal neuronal activity, an approach with certain advantages over electrical stimulation, the preferred investigational therapy for pharmacoresistant seizures. A computer model was developed to identify an efficient probe design and parameters that would allow cooling of brain tissue by no less than 21 degrees C in 30s, maximum. The Pennes equation and the… CONTINUE READING

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