Seizure clusters: A common, understudied and undertreated phenomenon in refractory epilepsy

  title={Seizure clusters: A common, understudied and undertreated phenomenon in refractory epilepsy},
  author={Arpitha Komaragiri and Kamil Detyniecki and Lawrence J. Hirsch},
  journal={Epilepsy \& Behavior},

Frequency of Seizure Clusters and Their Associated Risk Factors in Adult Patients with Epilepsy Referred to Epilepsy Center of Kashani Hospital in Isfahan from 2011 to 2016

Important risk factors that are found to be associated are age of onset, parental consanguinity, frequency of seizure, lack of have seizure-free period or periods, pathologies in neurological examination, and MRI findings.

Factors predisposing patients with temporal lobe epilepsy to seizure cluster

In patients with TLE, seizure clustering had no correlation with the epilepsy duration, the amount of IEDs, or brain MRI findings.

The Occurrence of Seizure Clusters in Patients With Epilepsy Is Partly Determined by Epilepsy Severity: A Single-Center Retrospective Observational Study

Seizure clusters (SCs) are common occurrences at the study center, and the occurrence of SC in individuals with epilepsy, to some extent, is determined by the epilepsy severity.

The correlation between cluster seizures and findings of magnetic resonance imaging in drug refractory epilepsy patients.

According to results of this study it seems that brain MRI findings of drug refractory epilepsy patients with a history of seizure clusters are different from brainMRI findings ofDrug Refractory Epilepsy patients without a historyof seizure clusters.

Updated review of rescue treatments for seizure clusters and prolonged seizures

Clinical opportunities for rescue medications, with particular attention focused on seizure clusters and prolonged seizures, are discussed, including their epidemiology, risk factors, and associated morbidity.

A critical evaluation of midazolam nasal spray for the treatment of patients with seizure clusters

  • J. Wheless
  • Medicine
    Expert review of neurotherapeutics
  • 2021
A critical evaluation of MDZ-NS for the treatment of patients with SCs is provided, which offers the benefits of intranasal administration, which allows for outpatient treatment by caregivers and other non-healthcare professionals when an SC occurs, and may be particularly meaningful to patients with limited treatment options because other routes of administration are unsuitable.



New-onset status epilepticus and cluster seizures in the elderly

Seizure clustering during drug treatment affects seizure outcome and mortality of childhood-onset epilepsy.

Cl clustering of seizures during treatment, but not prior to treatment, is associated with a poorer long-term seizure and mortality outcome, and patients with seizure clustering prior to, butNot during, treatment versus those with no clustering showed no difference in seizure outcome or mortality risk.

Prevalence of acute repetitive seizures (ARS) in the United Kingdom

Status Epilepticus and Acute Repetitive Seizures in Children, Adolescents, and Young Adults: Etiology, Outcome, and Treatment

Status epilepticus (SE) is one of the most common neurologic emergencies in children, adolescents, and young adults and treatment for RSE is difficult, usually requiring intensive support of vital functions.

The syndrome of frontal lobe epilepsy

It is concluded that frontal lobe epilepsy warrants aggressive investigation and that surgical treatment often can be successful, although high monthly seizure frequency and absence of a risk factors before age 5 occurred more often than is reported in temporal lobe epilepsy patients.

Identification and treatment of acute repetitive seizures in children and adults

  • J. Cereghino
  • Medicine, Psychology
    Current treatment options in neurology
  • 2007
Treatment for acute repetitive seizures should only be administered by caregivers who in the opinion of the prescriber are capable of monitoring the clinical response and recognize when the response is such that immediate professional evaluation or care is necessary.

Seizure Clustering: Risks and Outcomes

This preliminary study examined the prevalence of self‐reported clustering and identified potential risk factors and outcomes associated with reported clustering for further analysis in an ongoing prospective diary study.

Treating repetitive seizures with a rectal diazepam formulation

A single rectal dose of Diastat was significantly more effective than placebo in reducing the number of seizures following an episode of ARS, suggesting that caregivers could administer treatment safely and effectively in a nonmedical setting.