Seizure activity involved in the up-regulation of BDNF mRNA expression by activation of central mu opioid receptors.


Chemical-induced seizures up-regulated brain-derived neurotrophic factor (BDNF) mRNA expression. Intracerebroventricular (i.c.v.) administration of endogenous opioids preferentially activating mu opioid receptor (MOR) could also increase BDNF mRNA expression. The aim of this study was to determine to what extent i.c.v. administration of synthetic MOR… (More)
DOI: 10.1016/j.neuroscience.2009.03.020


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