Seizure Clustering: Risks and Outcomes

  title={Seizure Clustering: Risks and Outcomes},
  author={Sheryl R. Haut and Shlomo Shinnar and Solomon L Mosh{\'e}},
Summary:  Purpose: Patients with epilepsy often experience seizures in clusters. In this preliminary study, we examined the prevalence of self‐reported clustering and identified potential risk factors and outcomes associated with reported clustering for further analysis in an ongoing prospective diary study. 

Termination of seizure clusters is related to the duration of focal seizures

Examination of the characteristics of seizures that cluster is examined, with special attention to the final seizure in a cluster, to identify patients at increased morbidity risk.

Identifying seizure clusters in patients with epilepsy

Whether clustering is a true phenomenon in epilepsy and can be identified in the clinical setting and false positives can be determined with diary data is explored.

Seizure clusters

A review of current treatments for acute repetitive seizures aims to shed light on various aspects of seizure clusters with particular attention to their treatments.

The Occurrence of Seizure Clusters in Patients With Epilepsy Is Partly Determined by Epilepsy Severity: A Single-Center Retrospective Observational Study

Seizure clusters (SCs) are common occurrences at the study center, and the occurrence of SC in individuals with epilepsy, to some extent, is determined by the epilepsy severity.

Bursts of seizures in long‐term recordings of human focal epilepsy

We report on temporally clustered seizures detected from continuous long‐term ambulatory human electroencephalographic data. The objective was to investigate short‐term seizure clustering, which we

Seizure Clusters: Morbidity and Mortality

Understanding the effects of seizure frequency and duration on SUDEP risk could yield new insights in SUDEP pathophysiology and new targets for intervention.

Seizure clusters: characteristics and treatment.

  • S. Haut
  • Medicine
    Current opinion in neurology
  • 2015
Progress towards the development of nonintravenous routes of benzodiazepines has the potential to improve care in this area and greater focus on clarifying of definition and clinical implications is required.

Prevalence and risk factors of seizure clusters in adult patients with epilepsy




Seizure Clustering during Epilepsy Monitoring

Summary:  Purpose: To identify risk factors associated with seizure clustering during epilepsy monitoring and to assess the effect of clustering on localization of the epileptogenic zone.

The Association Between Seizure Clustering and Convulsive Status Epilepticus in Patients with Intractable Complex Partial Seizures

The association between seizure clustering and convulsive status epilepticus (SE) in patients with intractable complex partial seizures is examined to identify whether patients whose seizures typically cluster are at high risk for convulsive SE (CSE).

Seizure Lateralization During EEG Monitoring in Patients with Bilateral Foci: The Cluster Effect

: Purpose: To determine whether seizures that occur in clusters are more likely to reflect activity of the same focus than are seizures that are widely separated in time.

Antiepileptic Drug Withdrawal in Patients with Temporal Lobe Epilepsy Undergoing Presurgical Video‐EEG Monitoring

This data indicates that antiepileptic drug withdrawal during video‐EEG monitoring in adult patients with temporal lobe epilepsy (TLE) is disrupted during AED withdrawal.

[Etiology, follow-up and therapy of seizure clusters in temporal lobe epilepsy and catamenial epileptic seizures].

It is conjectured that endogenous, as well as exogenous factors, both of them not completely revealed, cause the occurrence of clusters; anticonvulsant drug therapy might even enlarge this trend.

Timing of Seizure Recurrence in Adult Epileptic Patients: A Statistical Analysis

The observations indicate that seizure cycling and/or clustering are not common in epileptic patients, but do not exclude the possibility that seizures have been precipitated by some randomly occurring event, such as sleep deprivation or increased stress.

An analysis of clinical seizure patterns and their localizing value in frontal and temporal lobe epilepsies.

The results of this study suggest that relatively few seizures can be localized reliably on clinical grounds and that even in those seizure types where there is a statistically significant association with specific cortical areas, an important minority do not share the same associations.

Proposal for Revised Classification of Epilepsies and Epileptic Syndromes

Results of a clinico-encephalographic study using proposal for classification of epilepsies and epileptic syndromes (1989 ILAE) showed that in 17 cases seizures could not be controlled in 6 of them, and an agreement is necessary for these problems.

Occurrence of seizure clusters and status epilepticus during inpatient video-EEG monitoring

Although status epilepticus is uncommon at epilepsy monitoring units, clusters of seizures are common, and intensive monitoring with drug withdrawal must be performed in a highly supervised, hospitalized setting.

Guidelines for Epidemiologic Studies on Epilepsy

The proposed guidelines represent a consensus between epileptologists and epidemiologists and are presented in four parts: Definition of seizures and epilepsy, (b) seizure type classification, (c) risk factors; and (d) recommended measurement indexes.