Seized designer supplement named “1-Androsterone”: Identification as 3β-hydroxy-5α-androst-1-en-17-one and its urinary elimination

  title={Seized designer supplement named “1-Androsterone”: Identification as 3$\beta$-hydroxy-5$\alpha$-androst-1-en-17-one and its urinary elimination},
  author={Maria Kristina Parr and Georg Opfermann and Hans Geyer and Folker Westphal and Frank D. S{\"o}nnichsen and Josef Zapp and Dorota Kwiatkowska and Wilhelm Schänzer},

Endocrine characterization of the designer steroid methyl-1-testosterone: investigations on tissue-specific anabolic-androgenic potency, side effects, and metabolism.

It was demonstrated that M1T is a potent androgenic and anabolic steroid after oral and sc administration and might exhibit liver toxicity, especially after oral administration.

Detection of 5α-androst-2-en-17-one and variants: Identification of main urinary metabolites in human urine samples by GC-MS and NMR.

Two steroids were identified in a supplement named D-2 following the detection of unknown compounds during the routine testing of an athlete's sample. The main glucuroconjugated metabolites were

Prohormone supplement 3β-hydroxy-5α-androst-1-en-17-one enhances resistance training gains but impairs user health.

The oral PS 3β-hydroxy-5α-androst-1-en-17-one improves body composition and muscular strength, but these changes come at a significant cost and the harm associated with this particular PS outweighs any potential benefit.

Sense or nonsense of prohormone designing : Reduced metandienone as supplement

  • Biology, Chemistry
  • 2012
To characterize the biological activity of 4,17-dimethylestra-1,3,5-trien-17β-ol it was tested in yeast androgen and estrogen receptor transactivation assays for agonistic and antagonistic effects, and was studied in a rat animal model.

N,N-dimethyl-2-phenylpropan-1-amine - new designer agent found in athlete urine and nutritional supplement.

The presence of the NN-DMPPA compound has been detected in the 'nutritional supplement' NOXPUMP that had been purchased in a store in Poland and it is important to make athletes aware of the risk related to the use of supplements.

N,N-dimethyl-2-phenylpropan-1-amine quantification in urine: application to excretion study following single oral dietary supplement dose

Exretion results demonstrate also that NN-DMPPA may be detected in urine samples by the applied GC-MS method till 46 h after supplement administration, and β-methylphenethylamine as the second prohibited substance present in the supplement NOXPUMP has been investigated.

Metabolism of boldione in humans by mass spectrometric techniques: detection of pseudoendogenous metabolites.

A method based on gas chromatography coupled to isotope ratio mass spectrometry (GC/C/IRMS) after a urine sample purification by high performance liquid chromatography (HPLC) permitted to confirm the main synthetic like boldione/boldenone metabolite.

Advances in the detection of designer steroids in anti-doping.

The structural modifications of the already known AAS to create new designer molecules are explained and progress in the detection of designer AAS using mass spectrometry and bioassays; analytical data processing of the unknown AAS; metabolite synthesis; and, long-term storage of urine and blood samples are discussed.

Non-targeted detection of designer androgens: Underestimated role of in vitro bioassays.

It is important to continue to develop new and effective detection approaches to prevent misuse of designer androgens and in vitro bioassays represent a potential solution to non-targeted detection strategies.



Another designer steroid: discovery, synthesis, and detection of 'madol' in urine.

A baboon administration study showed that madol and a metabolite are excreted in urine, and a method for rapid screening of urine samples by gas chromatography/mass spectrometry of trimethylsilylated madol was developed.

Analysis of the nutritional supplement 1AD, its metabolites, and related endogenous hormones in biological matrices using liquid chromatography-tandem mass spectrometry.

In vitro metabolism experiments using rat liver microsomes and testicular homogenates provided evidence for the interconversion of the three 1AD analogues, biosynthesis, and decomposition of several endogenous hormones, as well as evidence for 1AD analogue-induced changes in the typical profiles of testosterone and androstenedione in testicular tissue.

Detection of dihydrotestosterone (DHT) doping: alterations in the steroid profile and reference ranges for DHT and its 5 alpha-metabolites.

Alters in the concentrations and ratios of the DHT depending parameters for outside there reference ranges have been found and have been sanctioned on this basis by the Medical Commission of the Organisation of Olympic Council of Asia (OCA).

Tetrahydrogestrinone: discovery, synthesis, and detection in urine.

Sensitive and specific methods for rapid screening of urine samples by liquid chromatography/tandem mass spectrometry and NMR spectroscopy of underivatized Tetrahydrogestrinone and the combination trimethylsilyl ether-oxime derivative of THG are developed.

Complete 1H and 13C NMR spectral assignment of 17‐hydroxy epimeric sterols with planar A or A and B rings

Complete 1H and 13C spectral assignments of 17β‐ and 17α‐hydroxy epimers of three biologically active sterols (boldenone, 3‐methoxyestradiol and 3‐methoxydihydroequilenin) were achieved making use of

Detection of new 17-alkylated anabolic steroids

  • WADA
  • 2006

Prescription drugs and new anabolic steroids in nutritional supplements

  • Köln: Sport und Buch Strauß;
  • 2004

New designer anabolic steroids from internet

  • Köln: Sport und Buch Strauß;
  • 2006