Seized designer supplement named “1-Androsterone”: Identification as 3β-hydroxy-5α-androst-1-en-17-one and its urinary elimination

@article{Parr2011SeizedDS,
  title={Seized designer supplement named “1-Androsterone”: Identification as 3$\beta$-hydroxy-5$\alpha$-androst-1-en-17-one and its urinary elimination},
  author={Maria Kristina Parr and Georg Opfermann and Hans Geyer and Folker Westphal and Frank D. S{\"o}nnichsen and Josef Zapp and Dorota Kwiatkowska and Wilhelm Schänzer},
  journal={Steroids},
  year={2011},
  volume={76},
  pages={540-547}
}

Endocrine characterization of the designer steroid methyl-1-testosterone: investigations on tissue-specific anabolic-androgenic potency, side effects, and metabolism.

It was demonstrated that M1T is a potent androgenic and anabolic steroid after oral and sc administration and might exhibit liver toxicity, especially after oral administration.

Detection of 5α-androst-2-en-17-one and variants: Identification of main urinary metabolites in human urine samples by GC-MS and NMR.

Two steroids were identified in a supplement named D-2 following the detection of unknown compounds during the routine testing of an athlete's sample. The main glucuroconjugated metabolites were

Prohormone supplement 3β-hydroxy-5α-androst-1-en-17-one enhances resistance training gains but impairs user health.

The oral PS 3β-hydroxy-5α-androst-1-en-17-one improves body composition and muscular strength, but these changes come at a significant cost and the harm associated with this particular PS outweighs any potential benefit.

Sense or nonsense of prohormone designing : Reduced metandienone as supplement

  • Biology, Chemistry
  • 2012
To characterize the biological activity of 4,17-dimethylestra-1,3,5-trien-17β-ol it was tested in yeast androgen and estrogen receptor transactivation assays for agonistic and antagonistic effects, and was studied in a rat animal model.

N,N-dimethyl-2-phenylpropan-1-amine - new designer agent found in athlete urine and nutritional supplement.

The presence of the NN-DMPPA compound has been detected in the 'nutritional supplement' NOXPUMP that had been purchased in a store in Poland and it is important to make athletes aware of the risk related to the use of supplements.

N,N-dimethyl-2-phenylpropan-1-amine quantification in urine: application to excretion study following single oral dietary supplement dose

Exretion results demonstrate also that NN-DMPPA may be detected in urine samples by the applied GC-MS method till 46 h after supplement administration, and β-methylphenethylamine as the second prohibited substance present in the supplement NOXPUMP has been investigated.

Metabolism of boldione in humans by mass spectrometric techniques: detection of pseudoendogenous metabolites.

A method based on gas chromatography coupled to isotope ratio mass spectrometry (GC/C/IRMS) after a urine sample purification by high performance liquid chromatography (HPLC) permitted to confirm the main synthetic like boldione/boldenone metabolite.

Advances in the detection of designer steroids in anti-doping.

The structural modifications of the already known AAS to create new designer molecules are explained and progress in the detection of designer AAS using mass spectrometry and bioassays; analytical data processing of the unknown AAS; metabolite synthesis; and, long-term storage of urine and blood samples are discussed.

Non-targeted detection of designer androgens: Underestimated role of in vitro bioassays.

It is important to continue to develop new and effective detection approaches to prevent misuse of designer androgens and in vitro bioassays represent a potential solution to non-targeted detection strategies.

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