Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.
@article{Ebihara2015SeipinIN, title={Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.}, author={C. Ebihara and K. Ebihara and M. Aizawa-Abe and T. Mashimo and T. Tomita and M. Zhao and V. Gumbilai and T. Kusakabe and Y. Yamamoto and D. Aotani and S. Yamamoto-Kataoka and Takeru Sakai and K. Hosoda and T. Serikawa and K. Nakao}, journal={Human molecular genetics}, year={2015}, volume={24 15}, pages={ 4238-49 } }
Seipin, encoded by BSCL2 gene, is a protein whose physiological functions remain unclear. Mutations of BSCL2 cause the most-severe form of congenital generalized lipodystrophy (CGL). BSCL2 mRNA is highly expressed in the brain and testis in addition to the adipose tissue in human, suggesting physiological roles of seipin in non-adipose tissues. Since we found BSCL2 mRNA expression pattern among organs in rat is similar to human while it is not highly expressed in mouse brain, we generated a… Expand
35 Citations
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References
SHOWING 1-10 OF 42 REFERENCES
Seipin ablation in mice results in severe generalized lipodystrophy.
- Biology, Medicine
- Human molecular genetics
- 2011
- 133
- PDF
Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is a Cell-Autonomous Regulator of Lipolysis Essential for Adipocyte Differentiation
- Medicine, Biology
- Molecular and Cellular Biology
- 2012
- 120
- PDF
The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation.
- Biology, Medicine
- Endocrinology
- 2009
- 112
- PDF
Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice
- Medicine
- Diabetologia
- 2013
- 70
- PDF
Lack of seipin in neurons results in anxiety- and depression-like behaviors via down regulation of PPARγ.
- Biology, Medicine
- Human molecular genetics
- 2014
- 32
- PDF
Seipin: from human disease to molecular mechanism
- Biology, Medicine
- Journal of Lipid Research
- 2012
- 100
- PDF
Lack of testicular seipin causes teratozoospermia syndrome in men
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2014
- 48
- PDF
Human lipodystrophies: genetic and acquired diseases of adipose tissue.
- Biology, Medicine
- Endocrine development
- 2010
- 72
- PDF
Gene and phenotype analysis of congenital generalized lipodystrophy in Japanese: a novel homozygous nonsense mutation in seipin gene.
- Biology, Medicine
- The Journal of clinical endocrinology and metabolism
- 2004
- 43
- PDF
Seipinopathy: a novel endoplasmic reticulum stress-associated disease.
- Biology, Medicine
- Brain : a journal of neurology
- 2009
- 112
- PDF