Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.

@article{Ebihara2015SeipinIN,
  title={Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.},
  author={C. Ebihara and K. Ebihara and M. Aizawa-Abe and T. Mashimo and T. Tomita and M. Zhao and V. Gumbilai and T. Kusakabe and Y. Yamamoto and D. Aotani and S. Yamamoto-Kataoka and Takeru Sakai and K. Hosoda and T. Serikawa and K. Nakao},
  journal={Human molecular genetics},
  year={2015},
  volume={24 15},
  pages={
          4238-49
        }
}
Seipin, encoded by BSCL2 gene, is a protein whose physiological functions remain unclear. Mutations of BSCL2 cause the most-severe form of congenital generalized lipodystrophy (CGL). BSCL2 mRNA is highly expressed in the brain and testis in addition to the adipose tissue in human, suggesting physiological roles of seipin in non-adipose tissues. Since we found BSCL2 mRNA expression pattern among organs in rat is similar to human while it is not highly expressed in mouse brain, we generated a… Expand
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Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is Not Required for Brown Adipogenesis but Regulates Brown Adipose Tissue Development and Function
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Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode
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Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode
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Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals[S]
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Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse
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Does seipin play a role in oxidative stress protection and peroxisome biogenesis? New insights from human brain autopsies
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Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation
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Heterozygous deletion of Seipin in islet beta cells of male mice has an impact on insulin synthesis and secretion through reduced PPARγ expression
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Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance
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Seipin knockout impairs proliferation and differentiation of adult stem / progenitor cells in hippocampal dentate gyrus via reduction of PPARγ
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References

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