Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.

@article{Ebihara2015SeipinIN,
  title={Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.},
  author={C. Ebihara and K. Ebihara and M. Aizawa-Abe and T. Mashimo and T. Tomita and M. Zhao and V. Gumbilai and T. Kusakabe and Y. Yamamoto and D. Aotani and S. Yamamoto-Kataoka and Takeru Sakai and K. Hosoda and T. Serikawa and K. Nakao},
  journal={Human molecular genetics},
  year={2015},
  volume={24 15},
  pages={
          4238-49
        }
}
Seipin, encoded by BSCL2 gene, is a protein whose physiological functions remain unclear. Mutations of BSCL2 cause the most-severe form of congenital generalized lipodystrophy (CGL). BSCL2 mRNA is highly expressed in the brain and testis in addition to the adipose tissue in human, suggesting physiological roles of seipin in non-adipose tissues. Since we found BSCL2 mRNA expression pattern among organs in rat is similar to human while it is not highly expressed in mouse brain, we generated a… Expand
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