Seipin deficiency increases chromocenter fragmentation and disrupts acrosome formation leading to male infertility

@inproceedings{Zowalaty2015SeipinDI,
  title={Seipin deficiency increases chromocenter fragmentation and disrupts acrosome formation leading to male infertility},
  author={Ahmed E. El Zowalaty and Claudia Baumann and Rong Xin Li and Weiqin Chen and Rabindranath De La Fuente and X Ye},
  booktitle={Cell Death and Disease},
  year={2015}
}
The Berardinelli–Seip congenital lipodystrophy type 2 (Bscl2, seipin) gene is involved in adipogenesis. Bscl2−/− males were infertile but had normal mating behavior. Both Bscl2−/− cauda epididymis sperm count and sperm motility were ~20 × less than control. Bscl2−/− seminiferous tubules had relatively normal presence of spermatogonia and spermatocytes but had reduced spermatids and sperm. Spatiotemporal expression analyses in Bscl2+/+ testes demonstrated prominent Bscl2 transcriptional activity… CONTINUE READING
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