# Segregation of polymers in confined spaces

@article{Liu2012SegregationOP, title={Segregation of polymers in confined spaces}, author={Ya Liu and Bulbul Chakraborty}, journal={Physical Biology}, year={2012}, volume={9} }

We investigate the motion of two overlapping polymers confined in a 2D box. A statistical model is constructed using blob-free-energy arguments. We find spontaneous segregation under the condition L > R∥, and mixing under L < R∥, where L is the length of the box and R∥ is the polymer extension in an infinite slit. The segregation time (τ) is determined by solving a mean first-passage time problem and by performing Monte Carlo simulations. Both show a minimum in τ as a function of L. Although…

## 16 Citations

Segregation of polymers under cylindrical confinement: effects of polymer topology and crowding.

- Materials ScienceSoft matter
- 2018

Monte Carlo computer simulations are used to study the segregation behaviour of two polymers under cylindrical confinement and the conformational free energy, F, of the polymers was measured as a function of the centre-of-mass separation distance, λ, to identify discrepancies between the predicted and measured values of scaling exponents.

Polymer segregation under confinement: free energy calculations and segregation dynamics simulations.

- Materials ScienceThe Journal of chemical physics
- 2014

The free energy of the system, F, is measured as a function of the distance between the centers of mass of the polymers, λ, and the effects on the free energy functions of varying the channel diameter D and length L, as well as the polymer length N and bending rigidity κ are examined.

Equilibrium organization, conformation, and dynamics of two polymers under box-like confinement.

- PhysicsSoft matter
- 2021

Brownian dynamics and Monte Carlo simulations are used to study the conformation, organization and dynamics of two polymer chains confined to a single box-like cavity and the static and dynamical behaviour differs significantly from that previously observed for confinement of two polymers to a narrow channel.

Entropic Segregation of Ring Polymers in Cylindrical Confinement

- Physics
- 2015

Entropic forces tend to demix polymers in confinement, which has been argued to at least facilitate DNA segregation in cylindrical bacteria. Ring polymers as found in modern bacteria such as…

Segregation of ring polyelectrolytes in nano-channel.

- PhysicsThe Journal of chemical physics
- 2019

A segregation process of two ring polyions in the confined environment, represented by a tight nanopore, has been investigated by means of the nonequilibrium Monte Carlo method on the lattice.

Segregation of semiflexible macromolecules in nanochannel.

- PhysicsThe Journal of chemical physics
- 2013

Investigation of segregation of polymer coils in open channel was extended relative to previous studies and results indicate a stronger segregation tendency of flexible chains in channel relative to semiflexible chains both in its extent and dynamics.

Induction of entropic segregation: the first step is the hardest.

- BiologySoft matter
- 2014

It is demonstrated that the timescale for this induction phase is exponentially growing in the chain length, while the actual segregation time scales only quadratically in theChain length, and makes entropic segregation much less efficient than previously thought.

Ejection dynamics of semiflexible polymers out of a nanochannel

- Materials ScienceChinese Journal of Polymer Science
- 2016

Using theoretical analysis and three-dimensional Langevin dynamics simulations, we investigate the influence of chain rigidity on the ejection dynamics of polymers from a nanochannel. We find that…

Free Energy of a Folded Polymer under Cylindrical Confinement

- Physics
- 2017

Monte Carlo computer simulations are used to study the conformational free energy of a folded polymer confined to a long cylindrical tube. The polymer is modeled as a hard-sphere chain. Its…

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