Segregation of polymers in confined spaces

@article{Liu2012SegregationOP,
  title={Segregation of polymers in confined spaces},
  author={Ya Liu and Bulbul Chakraborty},
  journal={Physical Biology},
  year={2012},
  volume={9}
}
We investigate the motion of two overlapping polymers confined in a 2D box. A statistical model is constructed using blob-free-energy arguments. We find spontaneous segregation under the condition L > R∥, and mixing under L < R∥, where L is the length of the box and R∥ is the polymer extension in an infinite slit. The segregation time (τ) is determined by solving a mean first-passage time problem and by performing Monte Carlo simulations. Both show a minimum in τ as a function of L. Although… 
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16 Citations
Background Citations
1
Methods Citations
1

16 Citations

Segregation of polymers under cylindrical confinement: effects of polymer topology and crowding.
TLDR
Monte Carlo computer simulations are used to study the segregation behaviour of two polymers under cylindrical confinement and the conformational free energy, F, of the polymers was measured as a function of the centre-of-mass separation distance, λ, to identify discrepancies between the predicted and measured values of scaling exponents.
Polymer segregation under confinement: free energy calculations and segregation dynamics simulations.
TLDR
The free energy of the system, F, is measured as a function of the distance between the centers of mass of the polymers, λ, and the effects on the free energy functions of varying the channel diameter D and length L, as well as the polymer length N and bending rigidity κ are examined.
Equilibrium organization, conformation, and dynamics of two polymers under box-like confinement.
TLDR
Brownian dynamics and Monte Carlo simulations are used to study the conformation, organization and dynamics of two polymer chains confined to a single box-like cavity and the static and dynamical behaviour differs significantly from that previously observed for confinement of two polymers to a narrow channel.
Entropic Segregation of Ring Polymers in Cylindrical Confinement
Entropic forces tend to demix polymers in confinement, which has been argued to at least facilitate DNA segregation in cylindrical bacteria. Ring polymers as found in modern bacteria such as…
Segregation of ring polyelectrolytes in nano-channel.
  • W. Nowicki
  • Physics
    The Journal of chemical physics
  • 2019
TLDR
A segregation process of two ring polyions in the confined environment, represented by a tight nanopore, has been investigated by means of the nonequilibrium Monte Carlo method on the lattice.
Segregation of semiflexible macromolecules in nanochannel.
TLDR
Investigation of segregation of polymer coils in open channel was extended relative to previous studies and results indicate a stronger segregation tendency of flexible chains in channel relative to semiflexible chains both in its extent and dynamics.
Induction of entropic segregation: the first step is the hardest.
TLDR
It is demonstrated that the timescale for this induction phase is exponentially growing in the chain length, while the actual segregation time scales only quadratically in theChain length, and makes entropic segregation much less efficient than previously thought.
Ejection dynamics of semiflexible polymers out of a nanochannel
Using theoretical analysis and three-dimensional Langevin dynamics simulations, we investigate the influence of chain rigidity on the ejection dynamics of polymers from a nanochannel. We find that…
Free Energy of a Folded Polymer under Cylindrical Confinement
Monte Carlo computer simulations are used to study the conformational free energy of a folded polymer confined to a long cylindrical tube. The polymer is modeled as a hard-sphere chain. Its…
Coil–helix transition of biopolymer confined in finite cylinder
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