Segregation and linkage analysis of 40 multiplex multiple sclerosis families.

@article{Haile1981SegregationAL,
  title={Segregation and linkage analysis of 40 multiplex multiple sclerosis families.},
  author={Robert W Haile and Lennart Iselius and Susan E. Hodge and Newton E. Morton and Roger Detels},
  journal={Human heredity},
  year={1981},
  volume={31 4},
  pages={252-8}
}
40 multiplex multiple sclerosis (MS) families were analyzed for evidence of an MS susceptibility gene linked to the HLA region of the sixth chromosome. We assumed that population associations between specific HLA alleles and MS are due to linkage disequilibrium, so preference was given to hypotheses compatible with tight linkage, and explanations were sought for conflicting evidence. The analyses proceeded in two steps: (1) segregation analysis using the computer program POINTER, and (2… CONTINUE READING