Segregation and linkage analysis for longitudinal measurements of a quantitative trait

@article{Gee2003SegregationAL,
  title={Segregation and linkage analysis for longitudinal measurements of a quantitative trait},
  author={Conway Gee and John L Morrison and Duncan C Thomas and William James Gauderman},
  journal={BMC Genetics},
  year={2003},
  volume={4},
  pages={S21 - S21}
}
We present a method for using slopes and intercepts from a linear regression of a quantitative trait as outcomes in segregation and linkage analyses. We apply the method to the analysis of longitudinal systolic blood pressure (SBP) data from the Framingham Heart Study. A first-stage linear model was fit to each subject's SBP measurements to estimate both their slope over time and an intercept, the latter scaled to represent the mean SBP at the average observed age (53.7 years). The subject… CONTINUE READING

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