Segregation analysis of diabetic nephropathy in Pima Indians.

  title={Segregation analysis of diabetic nephropathy in Pima Indians.},
  author={Giuseppina Imperatore and William C. Knowler and David J. Pettitt and Sayuko Kobes and Peter H. Bennett and Robert L Hanson},
  volume={49 6},
Familial aggregation of diabetic nephropathy suggests the existence of genes determining susceptibility to nephropathy in addition to those leading to diabetes. In the present study, complex segregation analysis was performed in diabetic members of Pima Indian families to determine whether familial aggregation of nephropathy in this population could reflect the action of a single major gene. Nephropathy, defined by a urinary protein-to-creatinine ratio (PCR) > or = 500 mg/g, was analyzed as a… CONTINUE READING


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Albumin excretion in families with NIDDM is strongly influenced by a major gene: results of a segregation analysis

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