Segregation analysis of continuous phenotypes by using higher sample moments.

@article{Lee1996SegregationAO,
  title={Segregation analysis of continuous phenotypes by using higher sample moments.},
  author={H. Lee and Daniel O. Stram},
  journal={American journal of human genetics},
  year={1996},
  volume={58 1},
  pages={213-24}
}
The present article discusses the use of computational methods based on generalized estimating equations (GEE), as a potential alternative to full maximum-likelihood methods, for performing segregation analysis of continuous phenotypes by using randomly selected family data. The method that we propose can estimate effect and degree of dominance of a major gene in the presence of additional nongenetic or polygenetic familial associations, by relating sample moments to their expectations… CONTINUE READING