Segmenting the fly embryo: logical analysis of the role of the segment polarity cross-regulatory module.

@article{Snchez2008SegmentingTF,
  title={Segmenting the fly embryo: logical analysis of the role of the segment polarity cross-regulatory module.},
  author={Lucas S{\'a}nchez and Claudine Chaouiya and Denis Thieffry},
  journal={The International journal of developmental biology},
  year={2008},
  volume={52 8},
  pages={
          1059-75
        }
}
Initially activated by the pair-rule genes, the expression patterns of the segment polarity genes engrailed and wingless become consolidated through inter-cellular interactions between juxtaposed cells. We delineate a logical model focusing on a dozen molecular components at the core of the regulatory network controlling this process. Our model leads to the following conclusions: (1) the pair-rule signals, which activate engrailed and wingless genes independently of each other, need to be… CONTINUE READING

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