Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions

  title={Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions},
  author={Scott Fraser and Roger Keynes and Andrew G. S. Lumsden},
IN the chick embryo hindbrain, morphological segmentation into rhormbomeres is matched by metameric patterns of early neuronal differentiation and axonogenesis1. Boundaries between rhombomeres coincide with boundaries of expression of murine regulatory genes2–4. By clonal analysis using intracellular marking, we show here that the rhombomere boundaries are partitions across which cells do not move. When a parent cell is marked before the appearance of rhombomere boundaries, the resulting clone… CONTINUE READING
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