Segmental uniparental isodisomy on 5q32-qter in a patient with childhood-onset schizophrenia.

@article{Seal2006SegmentalUI,
  title={Segmental uniparental isodisomy on 5q32-qter in a patient with childhood-onset schizophrenia.},
  author={Johnny Seal and Michele C Gornick and Nitin Gogtay and Pamela Shaw and Deanna K. Greenstein and Michael Coffey and Peter A. Gochman and Tomas Stromberg and Z-Y. Chen and Brian Merriman and Stanley F. Nelson and Jane Brooks and Sampath Arepalli and Fabienne Wavrant-De Vri{\`e}ze and John S. Hardy and Judith L. Rapoport and Anjen{\'e} M Addington},
  journal={Journal of medical genetics},
  year={2006},
  volume={43 11},
  pages={887-92}
}
Schizophrenia is a severe mental disorder affecting approximately 1% of the world's population. Although the aetiology of schizophrenia is complex and multifactorial, with estimated heritabilities as high as 80%, genetic factors are the most compelling. Childhood-onset schizophrenia (COS), defined as onset of schizophrenia before the age of 13 years, is a rare and malignant form of the illness that may have more salient genetic influence. The first known case of paternal segmental uniparental… CONTINUE READING
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