Segmental regulation of pulmonary vascular permeability by store-operated Ca2+ entry.

@article{Chetham1999SegmentalRO,
  title={Segmental regulation of pulmonary vascular permeability by store-operated Ca2+ entry.},
  author={Paul M Chetham and Pavel Bab{\'a}l and James P. Bridges and Timothy Michael Moore and T. Christine Stevens},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={1999},
  volume={276 1},
  pages={L41-L50}
}
An intact endothelial cell barrier maintains normal gas exchange in the lung, and inflammatory conditions result in barrier disruption that produces life-threatening hypoxemia. Activation of store-operated Ca2+ (SOC) entry increases the capillary filtration coefficient ( K f,c) in the isolated rat lung; however, activation of SOC entry does not promote permeability in cultured rat pulmonary microvascular endothelial cells. Therefore, current studies tested whether activation of SOC entry… CONTINUE READING

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