Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q

  title={Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q},
  author={Pierluigi Strippoli and Pietro D'addabbo and Luca Lenzi and Sandra Giannone and Silvia Canaider and Raffaella Casadei and Lorenza Vitale and Paolo Carinci and Maria Zannotti},
  journal={Mammalian Genome},
Few cases of large-scale segmental paralogy have been reported in the human genome. We have identified a large (approximately 500 kb) segment on human chromosome (HC) 21 (21q22) that is triplicated on HC 1 (1p35) and HC 6 (6p12-21). We also identified a new member of CLIC (Chloride Intracellular Channel) family on 21q, namely CLIC6. All three segments appear to include three functional members of three different gene families: DSCR1-like (Down Syndrome Candidate Region 1-like), CLIC, and AML… 
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