Segmental homology and internal repetitiousness identified in putative nucleic acid polymerase and human hepatitis B surface antigen of human hepatitis B virus.

@article{Ohno1984SegmentalHA,
  title={Segmental homology and internal repetitiousness identified in putative nucleic acid polymerase and human hepatitis B surface antigen of human hepatitis B virus.},
  author={Susumu Ohno},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 12},
  pages={3781-5}
}
  • Susumu Ohno
  • Published 1984 in
    Proceedings of the National Academy of Sciences…
In a previous paper, it was argued that only those coding sequences descended from oligomeric repeats (the number of bases in the oligomeric unit not being a multiple of 3) can retain sufficiently long alternative open reading frames, and that such alternative open reading frames serve as the reservoir for the sudden generation of new polypeptide chains with novel functions. It was suggested that plasmid-encoded 6-amino hexanoic acid linear oligomer hydrolase that suddenly endowed… CONTINUE READING
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