Segmental folding of chromosomes: A basis for structural and regulatory chromosomal neighborhoods?

@inproceedings{Nora2013SegmentalFO,
  title={Segmental folding of chromosomes: A basis for structural and regulatory chromosomal neighborhoods?},
  author={Elph{\`e}ge P. Nora and Job Dekker and Edith Heard},
  booktitle={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2013}
}
We discuss here a series of testable hypotheses concerning the role of chromosome folding into topologically associating domains (TADs). Several lines of evidence suggest that segmental packaging of chromosomal neighborhoods may underlie features of chromatin that span large domains, such as heterochromatin blocks, association with the nuclear lamina and replication timing. By defining which DNA elements preferentially contact each other, the segmentation of chromosomes into TADs may also… CONTINUE READING
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