Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies.

@article{Dangl1988SegmentalFA,
  title={Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies.},
  author={Jeffery L. Dangl and Theodore G Wensel and Sherie L. Morrison and Lubert Stryer and Leonard A. Herzenberg and Vernon T. Oi},
  journal={The EMBO journal},
  year={1988},
  volume={7 7},
  pages={1989-94}
}
We generated a family of chimeric immunoglobulin G (IgG) molecules having identical antigen-combining sites for the dansyl (DNS) hapten, in conjunction with nine heavy chain constant (CH) regions. This family of antibody molecules allows comparison of CH dependent properties independent of possible variable region contributions to IgG function. The segmental flexibility and complement fixation activity were measured of six genetically engineered molecules (the four human IgG isotypes, mouse… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 90 extracted citations

Similar Papers

Loading similar papers…