Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain

@article{Wilkinson1989SegmentalEO,
  title={Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain},
  author={David G Wilkinson and Sangita Bhatt and Martyn Cook and Edorado Boncinelli and Robb K Krumlauf},
  journal={Nature},
  year={1989},
  volume={341},
  pages={405-409}
}
The vertebrate hindbrain develops in a segmental pattern, with distinctive groups of neurons originating from different segments. We report here that members of the Hox-2 cluster of murine homoeobox genes are expressed in segment-specific patterns in the developing hindbrain, with successive genes having boundaries at two-segment intervals. These data indicate that Hox genes specify segment phenotype, a role analogous to that of their Drosophila homologues. 
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