Segmental duplication, microinversion, and gene loss associated with a complex inversion breakpoint region in Drosophila.

@article{Calvete2012SegmentalDM,
  title={Segmental duplication, microinversion, and gene loss associated with a complex inversion breakpoint region in Drosophila.},
  author={Oriol Calvete and Josefa Gonz{\'a}lez and Esther Betr{\'a}n and Alfredo Ruiz},
  journal={Molecular biology and evolution},
  year={2012},
  volume={29 7},
  pages={1875-89}
}
Chromosomal inversions are usually portrayed as simple two-breakpoint rearrangements changing gene order but not gene number or structure. However, increasing evidence suggests that inversion breakpoints may often have a complex structure and entail gene duplications with potential functional consequences. Here, we used a combination of different techniques to investigate the breakpoint structure and the functional consequences of a complex rearrangement fixed in Drosophila buzzatii and… CONTINUE READING
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