Segmental differences in the roles of rho-kinase and protein kinase C in mediating vasoconstriction.

  title={Segmental differences in the roles of rho-kinase and protein kinase C in mediating vasoconstriction.},
  author={Klaudia Budzyn and Michelle Paull and Philip D. Marley and Christopher G Sobey},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={317 2},
Rho-kinase and protein kinase C (PKC) have each been reported to mediate vasoconstriction via calcium sensitization. However, the relative contributions of these two kinases to vascular contraction, and whether their roles vary between large and small arteries, are largely unknown. We therefore assessed the relative roles of rho-kinase and PKC in mediating vasoconstriction in arteries from three segments of the aortic and mesenteric vasculature. We studied contractile responses of rat isolated… CONTINUE READING


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