Segment-dependent Expression of Muscarinic Acetylcholine Receptors and G-protein Coupling in the Equine Respiratory Tract

@article{Abraham2006SegmentdependentEO,
  title={Segment-dependent Expression of Muscarinic Acetylcholine Receptors and G-protein Coupling in the Equine Respiratory Tract},
  author={Getu Abraham and Claudia Kottke and Hermann Ammer and Stefan Dhein and Fritz Rupert Ungemach},
  journal={Veterinary Research Communications},
  year={2006},
  volume={31},
  pages={207-226}
}
Muscarinic receptors are considered to be of comparable clinical importance in chronic obstructive pulmonary disease (COPD) in equines and in humans. At present, data are scarce on the expression and distribution of probable subtypes of these receptors and their signalling pathways in airway segments, including lung parenchyma and bronchial and tracheal epithelium with the underlying smooth muscle in horses. Specific [N-methyl-3H]scopolamine chloride ([3H]NMS) binding to all three tissues was… CONTINUE READING