Seeking an ancient enzyme in Methanococcus jannaschii using ORF, a program based on predicted secondary structure comparisons.

@article{Aurora1998SeekingAA,
  title={Seeking an ancient enzyme in Methanococcus jannaschii using ORF, a program based on predicted secondary structure comparisons.},
  author={Rajeev Aurora and George D. Rose},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 6},
  pages={
          2818-23
        }
}
  • Rajeev Aurora, George D. Rose
  • Published in
    Proceedings of the National…
    1998
  • Medicine, Biology
  • We have developed a simple procedure to identify protein homologs in genomic databases. The program, called ORF, is based on comparisons of predicted secondary structure. Protein structure is far better conserved than amino acid sequence, and structure-based methods have been effective in exploiting this fact to find homologs, even among proteins with scant sequence identity. ORF is a secondary structure-based method that operates solely on predictions from sequence and requires no… CONTINUE READING

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