Seeking an ancient enzyme in Methanococcus jannaschii using ORF, a program based on predicted secondary structure comparisons.

@article{Aurora1998SeekingAA,
  title={Seeking an ancient enzyme in Methanococcus jannaschii using ORF, a program based on predicted secondary structure comparisons.},
  author={R. Aurora and G. Rose},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 6},
  pages={
          2818-23
        }
}
  • R. Aurora, G. Rose
  • Published 1998
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
We have developed a simple procedure to identify protein homologs in genomic databases. The program, called ORF, is based on comparisons of predicted secondary structure. Protein structure is far better conserved than amino acid sequence, and structure-based methods have been effective in exploiting this fact to find homologs, even among proteins with scant sequence identity. ORF is a secondary structure-based method that operates solely on predictions from sequence and requires no… Expand
42 Citations
Identifying two ancient enzymes in Archaea using predicted secondary structure alignment
  • 39
  • PDF
Tandem clusters of membrane proteins in complete genome sequences.
  • 49
  • PDF
Biosynthesis of isoprenoids via mevalonate in Archaea: the lost pathway.
  • 162
  • PDF
Sequence-based detection of distantly related proteins with the same fold.
  • 6
  • PDF
Quod erat demonstrandum? The mystery of experimental validation of apparently erroneous computational analyses of protein sequences
  • 53
  • Highly Influenced
  • PDF
Analysis of conservation and substitutions of secondary structure elements within protein superfamilies
  • 23
  • PDF
An archaeal aminoacyl-tRNA synthetase missing from genomic analysis.
  • 15
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 52 REFERENCES
Extracting protein alignment models from the sequence database.
  • 269
  • PDF
The multiplicity of domains in proteins.
  • R. Doolittle
  • Biology, Medicine
  • Annual review of biochemistry
  • 1995
  • 497
Finding sequence motifs in groups of functionally related proteins.
  • 200
  • PDF
Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks.
  • 284
  • PDF
Deoxyuridylate-hydroxymethylase of bacteriophage SPO1.
  • 16
Protein fold recognition by mapping predicted secondary structures.
  • 137
  • PDF
...
1
2
3
4
5
...