Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown

  title={Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown},
  author={Luke Tweedy and P. Thomason and Peggy Paschke and Kirsty J. Martin and L. Machesky and M. Zagnoni and R. Insall},
  • Luke Tweedy, P. Thomason, +4 authors R. Insall
  • Published 2020
  • Computer Science, Medicine
  • Science
  • You can find your own way Migration of cells through tissues and embryos is often steered by gradients of attractive chemicals in a process called chemotaxis. Cells are best at navigating complex routes, for which they use “self-generated chemotaxis” and create their own attractant gradients. An example of this is when neutrophils migrate into tissues to attack infection. Using modeling and live-cell data, Tweedy et al. found that self-generated chemotaxis allows cells to obtain surprising… CONTINUE READING
    8 Citations


    Self-Generated Gradients Yield Exceptionally Robust Steering Cues
    • 4
    • PDF
    Directional tissue migration through a self-generated chemokine gradient
    • 269
    • PDF
    Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal
    • 77
    • PDF
    Microfluidic technologies for temporal perturbations of chemotaxis.
    • D. Irimia
    • Biology, Medicine
    • Annual review of biomedical engineering
    • 2010
    • 65
    Self-generated chemotactic gradients-cells steering themselves.
    • 21
    LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells
    • 22
    • PDF