Seeing GroEL at 6 A resolution by single particle electron cryomicroscopy.

  title={Seeing GroEL at 6 A resolution by single particle electron cryomicroscopy.},
  author={Steven J. Ludtke and D Chen and J L Song and David T Chuang and Wah Chiu},
  volume={12 7},
We present a reconstruction of native GroEL by electron cryomicroscopy (cryo-EM) and single particle analysis at 6 A resolution. alpha helices are clearly visible and beta sheet density is also visible at this resolution. While the overall conformation of this structure is quite consistent with the published X-ray data, a measurable shift in the positions of three alpha helices in the intermediate domain is observed, not consistent with any of the 7 monomeric structures in the Protein Data Bank… CONTINUE READING
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