Seeding specificity in amyloid growth induced by heterologous fibrils.

  title={Seeding specificity in amyloid growth induced by heterologous fibrils.},
  author={Brian O'Nuallain and Angela D. Williams and Per Westermark and Ronald Wetzel},
  journal={The Journal of biological chemistry},
  volume={279 17},
Over residues 15-36, which comprise the H-bonded core of the amyloid fibrils it forms, the Alzheimer's disease plaque peptide amyloid beta (Abeta) possesses a very similar sequence to that of another short, amyloidogenic peptide, islet amyloid polypeptide (IAPP). Using elongation rates to quantify seeding efficiency, we inquired into the relationship between primary sequence similarity and seeding efficiency between Abeta-(1-40) and amyloid fibrils produced from IAPP as well as other proteins… CONTINUE READING

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