See no evil, hear no evil, do no evil: the lessons of immune privilege

@article{Niederkorn2006SeeNE,
  title={See no evil, hear no evil, do no evil: the lessons of immune privilege},
  author={Jerry Y. Niederkorn},
  journal={Nature Immunology},
  year={2006},
  volume={7},
  pages={354-359}
}
Immune-mediated inflammation and allograft rejection are greatly reduced in certain organs, a phenomenon called 'immune privilege'. Immune privilege is well developed in three regions of the body: the eye, the brain and the pregnant uterus. Immune-mediated inflammation has devastating consequences in the eye and brain, which have limited capacity for regeneration. Likewise, loss of immune privilege at the maternal-fetal interface culminates in abortion in rodents. However, all three regions… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 158 extracted citations

Mechanisms of immune privilege in the anterior segment of the eye: what we learn from corneal transplantation

Journal of ocular biology, diseases, and informatics • 2008
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 115 references

A critical role for murine complement regulator crry in fetomaternal tolerVOLUME 7 NUMBER 4 APRIL

C Xu
2006

Regulatory T cells mediate maternal tolerance to the fetus

Aluvihare, V.R
Nat. Immunol • 2004

The induction of splenic suppressor T cells through an immune-privileged site requires an intact sympathetic nervous system

X Li
J. Neuroimmunol. 153, • 2004

Similar Papers

Loading similar papers…