Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition.

@article{Vistica2004SedimentationEA,
  title={Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition.},
  author={Jennifer Vistica and Julie Dam and Andrea Balbo and Emine Yikilmaz and Roy A. Mariuzza and Tracey A Rouault and Peter Schuck},
  journal={Analytical biochemistry},
  year={2004},
  volume={326 2},
  pages={234-56}
}
Sedimentation equilibrium is a powerful tool for the characterization of protein self-association and heterogeneous protein interactions. Frequently, it is applied in a configuration with relatively long solution columns and with equilibrium profiles being acquired sequentially at several rotor speeds. The present study proposes computational tools, implemented in the software SEDPHAT, for the global analysis of equilibrium data at multiple rotor speeds with multiple concentrations and multiple… CONTINUE READING
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