Sedative effects of the dopamine D1 receptor agonist A 68930 on rat open‐field behavior

  title={Sedative effects of the dopamine D1 receptor agonist A 68930 on rat open‐field behavior},
  author={Peter Salmi and Sven Ahl{\'e}nius},
The present results demonstrate sedative effects of the DA D1 receptor agonist A 68930 (0.9–15 μmol kg-1, s.c.) on rat spontaneous locomotor activity in an open field. The effects were particularly strong, and dose-dependent, for the ambulatory activity in the open-field arena (forward locomotion) and for rearing activity, whereas the suppression of locomotor activity (i.e. total horizontal activity in the open field) was less conspicuous. The distribution of activity within the open field… 

Differential effects of a selective dopamine D1-like receptor agonist on motor activity and c-fos expression in the frontal-striatal circuitry of SHR and Wistar-Kyoto rats

A potential alteration in D1R neurotransmission within the frontal-striatal circuitry of SHR involved in motor control is suggested, extending the understanding of the molecular alterations in SHR, a heuristically useful model of ADHD.

Locomotor activity and a conditioned fear response: correlation with cortical and subcortical binding of the dopamine D1 receptor antagonist [3H]SCH 23390

The present data indicate for the first time a significant, structure-dependent correlation between rat motor behavior and the dopamine D1 receptor ligand binding within the nigrostriatal system.

The adrenergic α2 receptor and sexual incentive motivation in male rats

Differential Response of Central Dopaminergic System in Acute and Chronic Unpredictable Stress Models in Rats

In insights into the differential regional response of dopaminergic system during AS and CUS are provided, neurochemical and behavioral effects of D1 agonist pretreatment suggest specific modulatory role of D2-like receptors under such stressful episodes.

Role of D1 receptor antagonism in contextual fear learning and memory

D1 receptors were found to be involved in the acquisition of contextual fear, and this modulation was found to occur in the dorsal hippocampus but not the amygdala, which could lead to a greater understanding of the mechanisms underlying anxiety disorders.



Serotonergic mechanisms in neuroleptic-induced catalepsy in the rat

  • M. Wadenberg
  • Biology, Psychology
    Neuroscience & Biobehavioral Reviews
  • 1996

Clozapine: dopamine D1 receptor agonism in the prefrontal cortex as the code to decipher a Rosetta stone of antipsychotic drugs.

  • S. Ahlénius
  • Psychology, Biology
    Pharmacology & toxicology
  • 1999
There are supporting clinical and laboratory observations implicating DA D1 receptors in the prefrontal cortex in cognitive functions, and clozapine displays features with regard to extrapyramidal motor mechanisms, and seizure thresholds, that could be explained by its properties as aDA D1 receptor agonist.

New insights into dopaminergic receptor function using antisense and genetically altered animals.

  • D. Sibley
  • Biology, Psychology
    Annual review of pharmacology and toxicology
  • 1999
This review discusses recent studies involving the use of genetic approaches for the study of dopaminergic receptor function using highly selective genetic approaches to alter the expression of individual dopamine receptor subtypes in vivo.

D1-like dopamine receptors: Regulation of psychomotor behaviour, D1-like interactions and effects of D1A targeted gene deletion

  • 1998