Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis

  title={Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis},
  author={S. Fern{\'a}ndez and C. Wasowski and A. Paladini and M. Marder},
  journal={Pharmacology Biochemistry and Behavior},
  • S. Fernández, C. Wasowski, +1 author M. Marder
  • Published 2004
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S (-) hesperidin (HN) in Valeriana officinalis and Valeriana wallichii. MA, in turn, was able to potentiate the sleep-inducing properties of HN. The present paper reports the identification in V. officinalis of the flavone glycoside linarin (LN) and the discovery that it has, like HN, sedative and sleep-enhancing properties that are potentiated by… CONTINUE READING
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