Sedation of critically ill patients during mechanical ventilation. A comparison of propofol and midazolam.

@article{Kress1996SedationOC,
  title={Sedation of critically ill patients during mechanical ventilation. A comparison of propofol and midazolam.},
  author={John Paul Kress and Michael F. O'Connor and Anne S. Pohlman and Doug Olson and Aubert Lavoie and Adi Toledano and Jesse Booth Hall},
  journal={American journal of respiratory and critical care medicine},
  year={1996},
  volume={153 3},
  pages={
          1012-8
        }
}
Propofol (P) and midazolam (M) are frequently given by continuous infusion for sedation in critically ill, mechanically ventilated patients. We compared these drugs with regard to: (1) time-to-awaken; (2) reproducibility of bedside assessments of level of sedation; (3) time-to-sedation; and (4) change in oxygen consumption (V O2) from awake to sedated state. Seventy-three patients were prospectively randomized to receive either P (n=37) or M (n=36). Wake-up times after stopping the drug were… CONTINUE READING
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