Securin depletion sensitizes human colon cancer cells to fisetin-induced apoptosis.

Abstract

Securin is highly-expressed in various tumors including those of the colon. In this study, the role of securin in the anticancer effects of fisetin on human colon cancer cells was investigated. Fisetin-induced apoptosis in HCT116 cells as indicated by TUNEL assay, Annexin V-FITC/PI double staining, Ser15-phosphorylation of p53, and cleavages of procaspase-3… (More)
DOI: 10.1016/j.canlet.2010.09.015

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@article{Yu2011SecurinDS, title={Securin depletion sensitizes human colon cancer cells to fisetin-induced apoptosis.}, author={Sz-Hsien Yu and Pei-Ming Yang and Chih-wen Peng and Yi-Chu Yu and Shu-Jun Chiu}, journal={Cancer letters}, year={2011}, volume={300 1}, pages={96-104} }