Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis.

@article{Zur2001SecurinDI,
  title={Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis.},
  author={A. Bar Zur and Michael Brandeis},
  journal={The EMBO journal},
  year={2001},
  volume={20 4},
  pages={
          792-801
        }
}
We have studied the ubiquitination and degradation patterns of the human securin/PTTG protein. We show that, in contrast to budding yeast pds1, securin degradation is catalyzed by both fzy (fizzy/cdc20) and fzr (fizzy-related/cdh1/hct1). Both fzy and fzr also induce the APC/C to ubiquitinate securin in vitro. Securin degradation is mediated by an RXXL destruction box and a KEN box, and is inhibited only when both sequences are mutated. Interestingly, the non-degradable securin mutant is also… CONTINUE READING

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