Secure route to the epoxybicyclo[7.3.0]dodecadienediyne core of the kedarcidin chromophore.

Abstract

Formation of an epoxide before 9-membered ring cyclization and SmI2 mediated reductive olefination in the presence of the epoxide successfully produced the epoxybicyclo[7.3.0]dodecadienediyne core of the kedarcidin chromophore. 
DOI: 10.1039/b814595d

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