Secukinumab: A Review in Moderate to Severe Plaque Psoriasis

  title={Secukinumab: A Review in Moderate to Severe Plaque Psoriasis},
  author={K. P. Garnock-jones},
  journal={American Journal of Clinical Dermatology},
  • K. P. Garnock-jones
  • Published 2015
  • Medicine
  • American Journal of Clinical Dermatology
  • Secukinumab (Cosentyx™) is a fully human monoclonal immunoglobulin G1κ antibody targeting human interleukin-17A, an important cytokine in the pathogenesis of psoriasis. Secukinumab, as well as being first in its drug class, is the first biologic treatment to be approved in the EU for the first-line systemic treatment of moderate to severe plaque psoriasis. This article reviews the pharmacologic properties of secukinumab and its clinical efficacy and tolerability in adult patients with moderate… CONTINUE READING
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