• Corpus ID: 50517779

Section 1: General Aspects of Vaccination How Do Vaccines Mediate Protection?

  title={Section 1: General Aspects of Vaccination How Do Vaccines Mediate Protection?},
  author={Claire-Anne Siegrist},
Disease control or elimination requires the induction of protective immunity in a suffi cient proportion of the population. This is best achieved by immunization programs capable of inducing long-term protection, a hallmark of adaptative immunity that contrasts to the brisk but short-lasting innate immune responses. Long-term immunity is conferred by the maintenance of antigen-specifi c immune effectors and/or by the induction of immune memory cells that may be suffi ciently effi cient and… 
2 Citations

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Investigation of the immunogenic potential of a non-specific porin, outer membrane protein C, whose expression is regulated by the two-component regulatory system and plays a major role in the survival of A. hydrophila indicates that rOmpC could serve as an effective vaccine against different strains of Aeromonas, a highly heterogenous group of bacteria.

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T cell vaccines for microbial infections

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Generation of improved mucosal vaccines by induction of innate immunity

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A greater understanding of innate immunity at mucosal surfaces and the mechanism of action of adjuvants and delivery systems is required to enhance the immunogenicity of these vaccines.

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Heterologous immunity and the nonspecific effects of vaccines: a major medical advance?

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Immunotherapy via dendritic cells.

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